'Scrubs' follows the unique view point of Dr. John 'J.D.' Dorian (Zach Braff). After leaving for a job at another hospital, J.D. returns to Sacred Heart to teach at its medical school alongside Chris Turk (Donald Faison), Perry Cox (John C. McGinley), Denise (Eliza Coupe) and Bob Kelso (Ken Jenkins).

Together they serve as professors (and inspiration) to a brand new class of med students, including the impressionable Lucy (Kerry Bishé), former med school drop out Drew (Michael Mosley), and cocky, entitled Cole (Dave Franco). As for his personal life, J.D. is now married to longtime sweetheart Dr. Elliot Reid (Sarah Chalke), and the happy couple is expecting their first child.